Androgen-Responsive Gene Database: Integrated Knowledge on Androgen-Responsive Genes
نویسندگان
چکیده
منابع مشابه
Regulatory regions of androgen-responsive genes.
Androgens are presumed to influence gene transcription by modifying the association of the androgen receptor with specific nuclear sites. However, the details of this process are still obscure. Elucidation of the mechanisms involved is complicated by the diversity of androgen binding within targetcell nuclei and by a lack of understanding of the interaction o f androgen receptors with androgen-...
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Persistent hepatitis B virus (HBV) infection is a major risk of hepatocellular carcinoma (HCC). One intriguing feature of HBV-related HCC is the male predominance, with a male to female ratio of 5-7:1. This dominance has been attributed to the elevated androgen level and the enhanced androgen receptor (AR)-mediated activity in the host. How HBV infection and AR signaling modulate HCC is unknown...
متن کاملIdentification of androgen-responsive microRNAs and androgen-related genes in breast cancer.
BACKGROUND Androgen receptors (ARs) are expressed in many breast cancer cells, but the mechanism of action of androgens is not as well-characterized as in other cell types. The study of microRNAs has recently provided with important insights into the biology of hormone-dependent cancer. MATERIALS AND METHODS We attempted to identify microRNAs induced by dihydrotestosterone in an AR-positive c...
متن کاملA competitive inhibitor that reduces recruitment of androgen receptor to androgen-responsive genes.
The androgen receptor (AR) has a critical role in the growth and progression of androgen-dependent and castration-resistant prostate cancers. To identify novel inhibitors of AR transactivation that block growth of prostate cancer cells, a luciferase-based high-throughput screen of ~160,000 small molecules was performed in cells stably expressing AR and a prostate-specific antigen (PSA)-lucifera...
متن کاملComplex modulation of androgen responsive gene expression by methoxyacetic acid
BACKGROUND Optimal androgen signaling is critical for testicular development and spermatogenesis. Methoxyacetic acid (MAA), the primary active metabolite of the industrial chemical ethylene glycol monomethyl ether, disrupts spermatogenesis and causes testicular atrophy. Transcriptional trans-activation studies have indicated that MAA can enhance androgen receptor activity, however, whether MAA ...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2009
ISSN: 0163-769X,1945-7189
DOI: 10.1210/edrv.30.6.9986